Dr. Balaz’s research is oriented towards the development of experimental and computational methods for determining drug disposition and receptor binding. In disposition, his lab performs experimental measurements using (1) surrogate phases to find structural determinants of transbilayer transport rates and accumulation in membranes and triglyceride phases, 和(2)结合到流行的人类蛋白质，如白蛋白和细胞外基质成分. 这些数据用于建立基于结构的模型，以预测药物的分布量和其他药代动力学特征. 这项工作的主要目标之一是为有限的分配找到调整药物结构的方法, 从而降低药物的细胞毒性，如用于治疗某些癌症或关节炎的药物.
Dr. Dearborn’s research focuses on development neurobiology in the fruit fly (Drosophila) in three primary areas: 1) The elucidation of vitamin D3 up-regulated protein 1 (VDUP1) tumor suppressor function during brain development, including VDUP1’s role in neural stem cell biology, 2) Hedgehog (Hh)依赖于VDUP1对细胞增殖的调控, 包括肿瘤细胞特异性Hh信号通路的差异如何影响药理治疗策略, 3) Eph受体信号通路的分子特征, which regulate axon guidance, vascular growth, and tumorigenesis. 该实验室在这些研究中强调分子遗传学方法, each with clinical and translational relevance.
Associate Professor and Director of Research
Dr. Hass’ research integrates synthetic organic chemistry, pharmaceutical formulation and stability, biochemical assays, medicinal chemistry, and pharmacology. 她的实验室为药物合成领域的学生提供培训机会, pharmaceutical formulation, topical drug delivery, and assessment of drug efficacy. 一个主要的重点领域是合成和活性的新药物，用于局部制剂治疗皮肤疾病. One group of novel co-drugs is designed to replenish natural antioxidants in the skin for enhanced and extended photoprotection relative to existing topical products. Other topical agents under development utilize the co-drug approach to target hyperproliferation of keratinocytes and inflammation associated with psoriasis.
抗微生物药物耐药性(AMR)对人类、动物和环境构成重大威胁. Dr. Jayachandran’s primary research interest is understanding the genetic basis of antibiotic resistance in methicillin-resistant Staphylococcus aureus (MRSA), a gram positive pathogen that causes nearly 11,000 deaths each year in the United States alone. 她的研究重点是SOS和压力(ROS)的作用, 抗生素)反应在获得抗生素耐药性金黄色葡萄球菌. Bacterial DNA damage stress response, also known as SOS response, 包括一组保守的基因，这些基因是在DNA受损的条件下诱导的. 其中包括涉及DNA修复通路的基因和易出错聚合酶的基因. 易出错聚合酶的表达增加导致突变率增加, which contribute to antibiotic resistance. RecA和LexA是此次SOS响应的主要调制器. Two main projects in the lab are: 1) Studying the effect of RecA inhibitors on the emergence of antibiotic resistance; 2) Identifying genes that play a role in SOS and stress response using a transposon mutant library. These studies will help us understand the pathogenicity and the mechanism of antibiotic resistance in MRSA and provide insights for the development of new therapeutics.
About 70% of estrogen receptor (ER) positive breast cancers have a significantly reduced risk of invasive breast cancer through the use of various endocrine therapies. 尽管它莫西芬和芳香化酶抑制剂具有相对的安全性和显著的抗肿瘤和化学预防活性, 许多最初反应性的乳腺肿瘤产生耐药性并最终复发. My current research is to investigate the secretome leading to the endocrine resistance in crosstalk between endocrine resistant breast cancer and tumor microenvironment. The long-term mission of my laboratory is to understand the steps of the endocrine resistant process in order to develop therapeutic approaches to prevent and treat endocrine resistant breast cancer effectively. The ultimate goal of my research is to bring therapies into the clinic that will improve the survival of metastatic breast cancer patients.
Dr. LaRocca的研究兴趣主要在于真核细胞程序性死亡(PCD)的机制. This includes the processes of apoptosis, necroptosis, 还有平衡这两种途径的分子开关. Dr. LaRocca对葡萄糖在驱动PCD中的作用特别感兴趣. He is actively investigating the mechanism of hyperglycemic cell death and its role in the exacerbation of ischemic brain injury (stroke). A second project in his lab is 这是一项由美国国家卫生研究院资助的基金，旨在增进对一种红细胞死亡的了解 这叫做尸体坏死，并探索影响这一过程的方法. Results from this work could one day lead to improved treatments for patients suffering from bacterial blood infections and other blood related disorders.
The long term research goal of Dr. Malik’s laboratory is to understand the complexities of host pathogen interactions for the development of improved prophylactics and therapeutics against important bacterial infections. She has a 由国立卫生研究院提供的三年资助 探讨土拉菌致病机制, a类生物威胁因子存在于免疫细胞内，抑制保护性免疫反应. A second area of focus is investigating the molecular mechanisms leading to the development of antibiotic resistance in methicillin resistant Staphylococcus aureus (MRSA) strains. Click the following PubMed link for 在博士学位进行的研究项目的附加信息. Malik's lab.
药代动力学研究和治疗药物监测, with the purpose of creating personalized therapeutic
Work in Dr. Shah's laboratory involves structural biology. He is currently investigating genetic polymorphisms in drug metabolizing Cytochrome P450 (CYP) enzymes using structural and biophysical methods. CYP是药物代谢的主要酶家族, and single nucleotide polymorphisms with amino acid substitutions are important contributors to interindividual variability in drug response. In brief, recombinant protein expression and purification are carried out in the laboratory in order to produce the quantities of CYP protein necessary for crystallization. The crystallographic data is collected remotely, 然后利用计算工具阐明蛋白质的三维结构.
Dr. Shi’s research interests are mainly focused on understanding the molecular basis of disease pathogenesis by using advanced molecular biology, virology, molecular genetics, and bioinformatics approaches. 实验室采用的方法包括:a) HIV-1感染性分子克隆, recombinant virus, and reporter gene technologies to study HIV phenotypes such as infection and replication; b) HIV-1 single genome amplification, 测序和生物信息学工具来了解基因型变化及其与疾病进展的关系. Another major area of interest in Dr. 施教授的实验室主要负责设计和开发用于检测传染病的诊断分析方法, monitoring disease progression, and managing treatments.
Dr. 辛格在研究与艾滋病发病有关的分子机制方面有广泛的科学背景, genomic imprinting, molecular biology and mouse models of disease. Dr. Singh的研究兴趣包括研究HIV相关神经紊乱的潜在分子机制, ii) HIV latency, 病毒感染诱发发育缺陷. Currently, Dr. 辛格的实验室专注于调查属于国家卫生研究院艾滋病高优先研究主题的两个项目. Project 1: To investigate the consequences of HIV (Human Immunodeficiency Virus) mediated downregulation of Sonic hedgehog (Shh) signaling on brain homeostasis with specific focus on aberrant communication between astrocytes and other brain-resident cells (brain endothelial cells, pericytes, microglia and neurons). 项目2:研究选定的非编码rna通过介导干扰素信号传导建立HIV潜伏期的潜力, ii)通过表观遗传机制调控HIV基因组的表达. 这些研究的成功完成将确定新的靶点，以减轻艾滋病发病机制，并为艾滋病的治疗铺平道路.
Research in Dr. 耶格尔的实验室致力于了解人体在流感感染期间是如何调节炎症反应的. Recent studies have established a critical role for the multi-protein cytosolic NLPR3 inflammasome complex in host defense and pathophysiology during flu infection. Specifically, Dr. Yager and his team are investigating how NLRP3 inflammasome activation and resultant inflammatory cytokine secretion are regulated on a molecular level to favor host protection over immunopathology. Other areas of research include the identification of novel targets for the development of new anti-viral drugs to combat flu infection and the role of viral-induced inflammation in the etiology and pathogenesis of autism spectrum disorder.
Dr. 郑的课题组对植物性复合药物(CDP)的设计和评估很感兴趣, peptides, and proteins from nature. 跨学科技术和转化策略被用于确保药品质量, elucidate mechanisms of action, and evaluate clinical benefits and risks. 这些努力可以帮助增强监管决策的能力，并实现以患者为中心的产品设计. 实验室目前的项目侧重于评估医用大麻产品的风险和好处. This includes studying the effects of botanical and endogenous cannabinoids on the brain and the blood brain interface (BBI) as well as investigating the endocannabinoid system (ECS) on drug delivery barriers.